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A great way to improve your pickup's fuel economy is to add a truck bed cover. A hard tri-fold tonneau cover will help reduce aerodynamic drag and can help with gas mileage. According to many experts by as much as 10%, see below for details.
2007 SEMA Study
According to the Federal Highway Administration average annual miles driven by males in the age group 35-54 is 18,858, visit their website for more details.